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What is carfentanil?

Carfentanil powder is an analogue of the synthetic opioid analgesic fentanyl.
Carfentanil is:

• 100 times stronger than the same amount of fentanyl
• 1.000 times stronger than heroin (by weight)
• A structural analogue of fentanyl
• A remedy with short duration of action and rapid onset of action
• Significantly more potent in its effect than other known opioids
• Used in veterinary medicine as an anesthetic for large animals

special feature: Carfentanil reduces pain response in rats more effectively than any other opioid.

Origin and development

• First synthesis: 1974
• Developed by: A team at Janssen Pharmaceutica
• Person involved: Paul Jansen
• Trade name in veterinary medicine: Wild Nile

Potency in comparison

Note: Carfentanil is not intended for human use due to its extreme potency.

Effect and receptor binding

Carfentanil/carfentanyl acts primarily as an agonist at the mu-opioid receptors.

Other receptors:

• Kappa receptors
• Delta receptors
• NMDA receptors
• Nicotinic acetylcholine receptors

Neurotransmitter release:

• Endorphine
• Serotonin
• Norepinephrine
• Adrenalin

Mechanism: In addition to opioid binding, carfentanil inhibits the reuptake of serotonin and noradrenaline.

Toxicity and lethal dose

Carfentanil is considered one of the deadliest substances in existence; even tiny doses are potentially fatal.

International availability and legal status

• In most countries Carfentanil illegal
• Anonymous online orders are recorded in Canada and Australia
• Partial use in research and veterinary medicine under strict regulation